Description

3,5-Di-tert-Butyl-4-Hydroxyphenylacetonitrile is a high-purity phenolic nitrile derivative, recognized as a versatile and critical synthetic intermediate in advanced chemical manufacturing. Its molecular structure, featuring sterically hindered phenolic and reactive nitrile groups, makes it a valuable precursor for synthesizing high-performance antioxidants, polymer stabilizers, and specialty fine chemicals. This compound is essential for R&D and production within the polymer additives, agrochemical, and pharmaceutical industries, where it serves as a key building block for creating molecules with enhanced stability and functionality.

Application

• Primary Intermediate for Antioxidants: A crucial starting material in the synthesis of high-performance phenolic antioxidants (e.g., hindered phenol antioxidants) used to stabilize polymers, plastics, and synthetic rubbers against thermal and oxidative degradation.
• Polymer Additive Synthesis: Used to manufacture light stabilizers and other polymer additives that extend the service life of polyolefins, PVC, and engineering plastics.
• Agrochemical Active Ingredients: Serves as a key synthon in the production of certain herbicides, fungicides, and plant growth regulators, contributing to the active molecule's stability and efficacy.
• Pharmaceutical Intermediates: Employed in the research and development of pharmaceutical compounds, particularly those requiring a sterically hindered phenolic moiety for biological activity or as a protective group.
• Fine Chemical and Dye Manufacturing: Acts as a building block for synthesizing complex organic molecules, including specialty dyes, pigments, and UV absorbers.
• Lubricant and Fuel Additives: Used in the formulation of additives that prevent oxidation and sludge formation in industrial lubricants and fuels.

Basic Information

Product Name	3,5-Di-tert-Butyl-4-Hydroxyphenylacetonitrile
CAS No.	1611-07-0
Molecular Formula	C₁₆H₂₃NO
Molecular Weight	245.36 g/mol
Synonyms	2-(3,5-Di-tert-butyl-4-hydroxyphenyl)acetonitrile; Cyanomethyl-3,5-di-tert-butyl-4-hydroxybenzene; 4-Hydroxy-3,5-di-tert-butylbenzyl cyanide; (3,5-Di-tert-butyl-4-hydroxyphenyl)acetonitrile; Benzenepropanenitrile, 4-hydroxy-3,5-bis(1,1-dimethylethyl)-; Antioxidant Intermediate 1611-07-0; Phenolic Nitrile Derivative
EINECS	Contact for details

Quality Control

Our 3,5-Di-tert-Butyl-4-Hydroxyphenylacetonitrile is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets exacting specifications for use as a high-value intermediate. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to guarantee traceability and consistency for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases. The material is light-sensitive; prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Melting Point	92 - 96 °C
Loss on Drying	≤ 0.5%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.