Description

2-Bromo-2,2-Difluoro-1-Phenyl-Ethanone is a versatile and highly reactive α-halo difluoromethyl ketone building block. Its unique structure, featuring both bromine and fluorine atoms on the α-carbon, makes it a critical intermediate for introducing the difluoroacetyl moiety into target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors seeking to develop novel active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of difluoromethyl ketone derivatives, which are important pharmacophores in drug discovery for protease inhibitors and other therapeutic agents.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the difluoromethyl group can improve compound efficacy and environmental profile.
• Material Science Research: Serves as a precursor for specialty monomers or polymers requiring fluorine incorporation to modify surface properties, chemical resistance, or thermal stability.
• Organic Synthesis Building Block: Employed in nucleophilic substitution and cross-coupling reactions to construct complex fluorinated organic molecules for various R&D applications.
• Ligand and Catalyst Development: Useful in the preparation of fluorinated ligands for catalysis or in the development of novel organofluorine compounds with specific electronic properties.

Basic Information

Product Name	2-Bromo-2,2-Difluoro-1-Phenyl-Ethanone
CAS No.	1610-04-4
Molecular Formula	C8H5BrF2O
Molecular Weight	235.03 g/mol
Synonyms	α-Bromo-α,α-difluoroacetophenone; Phenacyl Bromide, 2,2-Difluoro-; 2,2-Difluoro-2-bromo-1-phenylethanone; 2-Bromo-2,2-difluoroacetophenone; 1-Phenylethanone, 2-bromo-2,2-difluoro-; Difluorophenacyl Bromide; (Bromodifluoroacetyl)benzene; EINECS 216-548-8
EINECS	216-548-8

Quality Control

Our 2-Bromo-2,2-Difluoro-1-Phenyl-Ethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids, bases, and incompatible organic solvents. Due to its light-sensitive nature, containers should be amber-colored or stored in dark conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.