Description

1,4,5,6-Tetrahydropyrimidine is a versatile heterocyclic organic compound with a partially saturated pyrimidine ring structure, serving as a key building block in advanced chemical synthesis. Its unique scaffold is highly valued for introducing the tetrahydropyrimidine moiety into target molecules, which is crucial for modulating biological activity and physical properties. This intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of various drug candidates, particularly those targeting central nervous system (CNS) disorders, cardiovascular diseases, and anti-infective agents.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the tetrahydropyrimidine core contributes to biological efficacy.
• Ligand and Catalyst Preparation: Serves as a starting material or ligand framework for constructing metal complexes used in asymmetric catalysis and organic transformations.
• Chemical Research & Development: A valuable scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis for high-throughput screening.
• Specialty Polymer Modifier: Incorporated into polymer chains to impart specific characteristics like modified solubility, thermal stability, or coordination sites.

Basic Information

Product Name	1,4,5,6-Tetrahydropyrimidine
CAS No.	1606-49-1
Molecular Formula	C4H8N2
Molecular Weight	84.12 g/mol
Synonyms	1,4,5,6-Tetrahydro-2(1H)-pyrimidinone (tautomer); Dihydrouracil; 2-Oxohexahydropyrimidine; 1,3-Diazinane-2-one; NSC 403697; Uracil, dihydro-; Hexahydro-2-pyrimidinone
EINECS	216-529-8

Quality Control

Our 1,4,5,6-Tetrahydropyrimidine is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure it meets the high-purity standards required for research and industrial synthesis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to guarantee traceability and compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.