Description

1H-Indole-3-Acetic Acid, 1-(4-Chlorobenzoyl)-5-Methoxy-2-Methyl-, 1,1-Dimethylethyl Ester is a high-purity synthetic indole derivative, a crucial advanced pharmaceutical intermediate designed for the development of novel therapeutic agents. Its complex molecular architecture, featuring both indole and chlorobenzoyl moieties, makes it a valuable building block for medicinal chemistry research and process development. This compound is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of specialized active pharmaceutical ingredients (APIs).

Application

This specialized indole ester serves as a key precursor in advanced synthetic pathways. Its primary and potential applications include:

• Pharmaceutical Intermediate: Core building block for the research and synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize the potency and selectivity of lead compounds.
• Process Chemistry Development: Serves as a critical intermediate in scaling up synthetic routes from laboratory to pilot plant and commercial production.
• Reference Standard: High-purity material suitable for use as an analytical standard in quality control and method development for API manufacturing.
• Biochemical Research: Potential tool compound for studying biological pathways involving indole-based signaling molecules.

Basic Information

Product Name	1H-Indole-3-Acetic Acid, 1-(4-Chlorobenzoyl)-5-Methoxy-2-Methyl-, 1,1-Dimethylethyl Ester
CAS No.	1601-20-3
Molecular Formula	C23H24ClNO4
Molecular Weight	413.90 g/mol
Synonyms	tert-Butyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate; 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic Acid 1,1-Dimethylethyl Ester; 1-(p-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic Acid tert-Butyl Ester; Indomethacin tert-Butyl Ester Derivative; Indole-3-acetic Acid tert-Butyl Ester Derivative; CAS 1601-20-3
EINECS	Contact for details

Quality Control

Our production of this advanced pharmaceutical intermediate adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability. The material is manufactured under controlled GMP-like conditions suitable for pharmaceutical development. Identity, purity, and impurity profiles are rigorously verified using advanced analytical techniques including HPLC, GC, and NMR. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The container should be kept tightly sealed to protect the integrity of the material from environmental factors.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.