Description

Methyl 1-(4-Chlorobenzoyl)-5-Methoxy-2-Methyl-1H-Indole-3-Acetate is a high-purity, non-steroidal anti-inflammatory drug (NSAID) intermediate of significant commercial importance. Its primary value lies in its role as a key synthetic precursor in the production of pharmaceutical active ingredients, ensuring supply chain reliability for critical drug manufacturing. This compound is essential for pharmaceutical R&D laboratories and API manufacturers focused on developing and producing anti-inflammatory and analgesic medications.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of NSAID (Non-Steroidal Anti-Inflammatory Drug) active pharmaceutical ingredients (APIs).
• API Synthesis: Used in the research, development, and commercial-scale production of specific indole-based therapeutic agents.
• Chemical Research: Serves as a valuable reference standard and starting material in medicinal chemistry and process development for novel drug candidates.
• Preclinical Studies: Employed in the formulation of compounds for pharmacological evaluation and toxicology assessments.

Basic Information

Product Name	Methyl 1-(4-Chlorobenzoyl)-5-Methoxy-2-Methyl-1H-Indole-3-Acetate
CAS No.	1601-18-9
Molecular Formula	C21H20ClNO4
Molecular Weight	385.84 g/mol
Synonyms	Indomethacin Methyl Ester; Methyl Indomethacin; 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid methyl ester; 5-Methoxy-2-methyl-1-(4-chlorobenzoyl)indole-3-acetic acid methyl ester; 1-(p-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid methyl ester; CL-84777; Indometacin Methyl Ester
EINECS	Contact for details

Quality Control

Our Methyl 1-(4-Chlorobenzoyl)-5-Methoxy-2-Methyl-1H-Indole-3-Acetate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical synthesis. Each lot undergoes comprehensive analytical testing, including HPLC for assay and impurity profiling. A Certificate of Analysis (COA) detailing identity, purity, and related substances is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.