Description

Ethyl 1-Cyanocyclopropanecarboxylate is a versatile and high-value organic building block featuring a cyclopropane ring functionalized with both cyano and ester groups. This unique structure makes it a critical intermediate in the synthesis of complex molecules, particularly in the pharmaceutical and agrochemical sectors. It is primarily sought after by R&D chemists and process development scientists for constructing constrained ring systems and introducing functional handles for further derivatization. Its application is central to modern medicinal chemistry, enabling the exploration of novel bioactive compounds.

Application

• Pharmaceutical Intermediate: Key synthon for the preparation of active pharmaceutical ingredients (APIs), especially those containing cyclopropane motifs, which are common in antiviral, anticancer, and CNS-targeting drugs.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the cyclopropane ring can enhance biological activity and environmental stability.
• Material Science Research: Serves as a precursor for specialty monomers or polymers with unique thermal or mechanical properties derived from the strained ring system.
• Organic Synthesis Building Block: Employed in cycloaddition reactions, ring-opening transformations, and as a scaffold for constructing complex natural product analogs and chemical libraries.
• Fine Chemical Production: Integral to the multi-step synthesis of dyes, flavors, fragrances, and other high-value specialty chemicals.

Basic Information

Product Name	Ethyl 1-Cyanocyclopropanecarboxylate
CAS No.	1558-81-2
Molecular Formula	C7H9NO2
Molecular Weight	139.15 g/mol
Synonyms	1-Cyano-1-cyclopropanecarboxylic acid ethyl ester; Ethyl 1-cyanocyclopropane-1-carboxylate; 1-Cyanocyclopropanecarboxylic Acid Ethyl Ester; Cyclopropanecarbonitrile, 1-ethoxycarbonyl-; 1-Ethoxycarbonylcyclopropanecarbonitrile; 1-Carbethoxy-1-cyanocyclopropane; Ethyl 1-Cyano-1-cyclopropanecarboxylate
EINECS	Contact for details

Quality Control

Every batch of Ethyl 1-Cyanocyclopropanecarboxylate is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for research and commercial synthesis. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.