Description

4-Amino-2,3,5,6-Tetrafluorobenzamide is a high-purity fluorinated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring a tetrafluorinated benzene ring with adjacent amino and amide functional groups, makes it a versatile intermediate for creating complex molecules with tailored properties. This compound is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and pesticides, where the fluorine atoms enhance biological activity, metabolic stability, and lipophilicity.
• Material Science Research: Serves as a building block for advanced polymers, liquid crystals, and organic electronic materials due to its electron-deficient aromatic core and potential for further functionalization.
• Fluorinated Dye & Pigment Intermediate: Employed in the creation of specialized dyes and pigments with improved lightfastness and chemical resistance for high-performance applications.
• Cross-Coupling Reactions: The amino group can be used for Buchwald-Hartwig amination or other palladium-catalyzed couplings to construct complex biaryl and heteroaryl structures.

Basic Information

Product Name	4-Amino-2,3,5,6-Tetrafluorobenzamide
CAS No.	1548-74-9
Molecular Formula	C7H4F4N2O
Molecular Weight	208.11 g/mol
Synonyms	2,3,5,6-Tetrafluoro-4-aminobenzamide; 4-Amino-2,3,5,6-tetrafluorobenzoic acid amide; 4-Aminotetrafluorobenzamide; 2,3,5,6-Tetrafluoro-4-aminobenzamide; 4-Amino-perfluorobenzamide; Benzamide, 4-amino-2,3,5,6-tetrafluoro-; 4-Amino-2,3,5,6-tetrafluorobenzamide (Tetrafluoroanthranilamide)
EINECS	Contact for details

Quality Control

Our 4-Amino-2,3,5,6-Tetrafluorobenzamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and scale-up applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The product may be hygroscopic; keep the container tightly sealed to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.