Description

1-(Trifluoroacetyl)Imidazole is a versatile and highly reactive trifluoroacetylating agent used in organic synthesis. Its core value lies in its ability to efficiently introduce the trifluoroacetyl group, a key moiety for modifying chemical properties like lipophilicity and metabolic stability. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity intermediates for complex synthesis.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly those requiring trifluoromethyl groups to enhance bioavailability and potency.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the trifluoroacetyl group contributes to efficacy and environmental profile.
• Peptide Chemistry: Acts as a protecting and activating agent in the synthesis of modified peptides and peptidomimetics.
• Material Science: Intermediate in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: Serves as a precursor or reagent in palladium-catalyzed and other metal-mediated coupling reactions.
• Derivatization Agent: Used in analytical chemistry for the derivatization of compounds to improve detection in GC or HPLC analysis.

Basic Information

Item	Details
Product Name	1-(Trifluoroacetyl)Imidazole
CAS No.	1546-79-8
Molecular Formula	C5H3F3N2O
Molecular Weight	164.09 g/mol
Synonyms	N-(Trifluoroacetyl)imidazole; Trifluoroacetic acid imidazolide; Trifluoroacetic imidazolide; Imidazole, 1-(trifluoroacetyl)-; 1H-Imidazole, 1-(trifluoroacetyl)-; TFAl; TFAI; Trifluoroacetylimidazole
EINECS	Contact for details

Quality Control

Our 1-(Trifluoroacetyl)Imidazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available for every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its highly volatile and moisture-sensitive nature, keep the container tightly sealed under an inert atmosphere when not in use. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.