Description

1,1,2-Trifluoro-2-Chloro-3-Cyano Cyclobutane is a high-value, multi-functional fluorinated cyclobutane derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its unique structure, featuring a reactive cyano group and halogenated fluorines on a strained four-membered ring, makes it an indispensable building block for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the development of fluorinated drug candidates, including protease inhibitors and CNS-active molecules.
• Agrochemical Synthesis: Building block for novel herbicides and pesticides, leveraging the stability and lipophilicity imparted by the fluorine atoms.
• Material Science Research: Used in the synthesis of specialty polymers and liquid crystals where the cyclobutane core and fluorine content modify thermal and optical properties.
• Organic Synthesis Reagent: Serves as a versatile precursor for ring-opening and functional group transformation reactions in complex molecule assembly.
• Fluorine Chemistry Studies: A valuable compound for academic and industrial research into the reactivity of fluorinated, strained-ring systems.

Basic Information

Product Name	1,1,2-Trifluoro-2-Chloro-3-Cyano Cyclobutane
CAS No.	1546-77-6
Molecular Formula	C5H2ClF3N
Molecular Weight	159.52 g/mol
Synonyms	2-Chloro-1,1,2-trifluoro-3-cyanocyclobutane; 3-Cyano-2-chloro-1,1,2-trifluorocyclobutane; 1,1,2-Trifluoro-2-chlorocyclobutane-3-carbonitrile; 2-Chloro-1,1,2-trifluorocyclobutane-3-carbonitrile; Cyclobutane-3-carbonitrile, 2-chloro-1,1,2-trifluoro-; 1546-77-6; Trifluorochlorocyanocyclobutane
EINECS	Contact for details

Quality Control

Every batch of 1,1,2-Trifluoro-2-Chloro-3-Cyano Cyclobutane is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for each lot and provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong acids, organic solvents, fluorides, and strong alkalis. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Individual Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.