Description

Trifluoroacetic Acid Hydrazide is a specialized fluorinated organic compound that serves as a versatile building block in advanced chemical synthesis. Its unique structure, featuring a reactive hydrazide group attached to a trifluoroacetyl moiety, makes it a critical reagent for introducing the trifluoromethyl group and for constructing nitrogen-containing heterocycles. This high-value intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients with enhanced properties.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing trifluoromethyl groups which improve metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the fluorine atoms contribute to increased efficacy and environmental persistence.
• Heterocyclic Chemistry: Fundamental building block for constructing pyrazoles, triazoles, and other nitrogen-based heterocycles, which are core scaffolds in many bioactive molecules.
• Peptide Modification & Labeling: Employed in biochemical research for modifying peptides and proteins, often used to introduce fluorinated tags or as a coupling agent.
• Material Science Research: Serves as a monomer or modifier in the development of specialty polymers and advanced materials with specific surface properties.
• Cross-coupling Reagent: Acts as a reagent in palladium-catalyzed and other cross-coupling reactions to form carbon-nitrogen and carbon-carbon bonds.

Basic Information

Item	Details
Product Name	Trifluoroacetic Acid Hydrazide
CAS No.	1538-08-5
Molecular Formula	C2H3F3N2O
Molecular Weight	128.05 g/mol
Synonyms	2,2,2-Trifluoroacetohydrazide; Trifluoroacetohydrazide; TFH; TFAH; Trifluoroacetylhydrazine; Hydrazine, trifluoroacetyl-; NSC 404058; 2,2,2-Trifluoroacetic acid hydrazide
EINECS	Contact for details

Quality Control

Our Trifluoroacetic Acid Hydrazide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive quality assurance, with specifications typically meeting or exceeding 98.0% minimum purity (by HPLC). Each batch is accompanied by a detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profiles. Our quality protocols are designed to support cGMP compliance for pharmaceutical applications, and we can accommodate custom purity grades and analytical requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.