Description

[(Difluoromethyl)Thio]Benzene CAS NO 1535-67-7 is a specialized organosulfur and organofluorine compound, serving as a valuable building block in advanced chemical synthesis. Its unique difluoromethylthio (-SCF2H) group makes it a key reagent for introducing fluorinated sulfur motifs, which are critical for modulating the physicochemical properties of target molecules. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries who require reliable, high-quality fluorination reagents.

Application

• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs), particularly for incorporating the difluoromethylthioether group to enhance metabolic stability and membrane permeability.
• Agrochemical Synthesis: Serves as a key precursor in developing novel herbicides, fungicides, and insecticides where fluorine substitution improves efficacy and environmental profile.
• Material Science Research: Employed in the creation of advanced polymers and functional materials with specific surface properties or reactivity.
• Ligand and Catalyst Development: Utilized in organometallic chemistry to prepare novel ligands for catalysis, especially in cross-coupling reactions.
• Fluorine Chemistry Reagent: Acts as a versatile electrophilic or nucleophilic reagent for introducing the -SCF2H moiety into complex organic frameworks.
• Life Science Probes: Potential use in the design of biochemical probes and imaging agents due to the properties of the fluorine atoms.

Basic Information

Product Name	[(Difluoromethyl)Thio]Benzene
CAS No.	1535-67-7
Molecular Formula	C7H6F2S
Molecular Weight	160.18 g/mol
Synonyms	Benzenethiol, (difluoromethyl)-; (Difluoromethyl)phenyl sulfide; alpha,α-Difluorothioanisole; Phenyl(difluoromethyl) sulfide; S-(Difluoromethyl) benzenethiol; Difluoromethyl phenyl thioether; 1-(Difluoromethylsulfanyl)benzene
EINECS	Contact for details

Quality Control

Our [(Difluoromethyl)Thio]Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatography and spectroscopy, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in the original packaging or amber glass until use.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.