Description

4-Chloro-4,4-Difluoro-2-Butanone is a versatile fluorinated ketone building block, recognized for its unique reactivity profile. This compound is valued for its ability to introduce both chloro and difluoromethyl groups into target molecules, enabling the synthesis of complex, high-value intermediates. It is primarily sought after by R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the development of novel active pharmaceutical ingredients (APIs), particularly for introducing fluorinated motifs to enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the difluoro and chloro functionalities contribute to biological activity and environmental persistence.
• Organic Synthesis Building Block: Serves as a versatile electrophile in nucleophilic substitution reactions and as a precursor for further functionalization in custom synthesis and contract research.
• Fluorinated Material Precursor: Employed in the research and development of specialty polymers, liquid crystals, and electronic chemicals that require specific fluorinated segments.
• Chemical Research & Development: Utilized in academic and industrial labs for methodological studies and exploring new reaction pathways involving α-halogenated fluoroketones.

Basic Information

Product Name	4-Chloro-4,4-Difluoro-2-Butanone
CAS No.	1515-16-8
Molecular Formula	C4H5ClF2O
Molecular Weight	142.53 g/mol
Synonyms	4-Chloro-4,4-difluorobutan-2-one; 1-Chloro-1,1-difluoroacetone; 4-Chloro-4,4-difluoro-2-butanone; 2-Butanone, 4-chloro-4,4-difluoro-; 4-Chloro-4,4-difluoro-2-oxobutane; 1-Chloro-1,1-difluoro-3-butanone; 4-Chloro-4,4-difluorobutanone
EINECS	Contact for details

Quality Control

Our 4-Chloro-4,4-Difluoro-2-Butanone is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chromatography and spectroscopy, to ensure identity, purity, and consistency. A Certificate of Analysis (COA) detailing specific results is provided with every shipment to guarantee it meets your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its highly volatile nature, keep away from heat, sparks, and open flame. Containers should be kept tightly sealed when not in use to prevent evaporation and potential moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.