Description

n-Acetylnorvaline Methyl Ester is a protected amino acid derivative, specifically the methyl ester of N-acetylated norvaline. This compound serves as a crucial chiral building block and intermediate in sophisticated organic synthesis, offering a protected amine and carboxylic acid group for selective reactions. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptides, peptidomimetics, and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic peptides and small molecule drugs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis as a protected amino acid building block to construct specific peptide sequences.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies and metabolic pathway investigations.
• Prodrug Development: Serves as a precursor in designing prodrugs where the ester moiety can be cleaved in vivo.
• Chemical Biology Probes: Utilized in the synthesis of labeled or modified amino acids for proteomics and cellular studies.
• Asymmetric Synthesis: Acts as a starting material or auxiliary in catalytic asymmetric reactions to introduce chirality.

Basic Information

Product Name	n-Acetylnorvaline Methyl Ester
CAS No.	1492-17-7
Molecular Formula	C8H15NO3
Molecular Weight	173.21 g/mol
Synonyms	N-Acetylnorvaline Methyl Ester; Methyl N-Acetylnorvalinate; Methyl 2-Acetamidopentanoate; 2-Acetamidopentanoic Acid Methyl Ester; L-Norvaline, N-acetyl-, methyl ester; Norvaline, N-acetyl-, methyl ester; Ac-Nva-OMe; N-Acetyl-L-norvaline methyl ester
EINECS	Contact for details

Quality Control

Our n-Acetylnorvaline Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.