Description

Pyrimidine-5-Boronic Acid is a high-value boronic acid derivative and a key synthetic building block in modern organic chemistry. Its primary value lies in its role as a versatile coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex heterocyclic systems. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries, where it is used to develop active pharmaceutical ingredients (APIs), advanced crop protection agents, and functional organic materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly for kinase inhibitors, antiviral agents, and other small molecule therapeutics.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Material Science Research: Serves as a building block for organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Chemical Biology & Proteomics: Employed in the development of molecular probes and inhibitors for studying enzyme function and biological pathways.
• Academic & R&D Laboratories: A fundamental reagent for methodological development in cross-coupling chemistry and heterocycle synthesis.
• Ligand Synthesis: Used to prepare sophisticated boronic acid-based ligands for catalysis and sensor applications.

Basic Information

Product Name	Pyrimidine-5-Boronic Acid
CAS No.	1446-27-1
Molecular Formula	C4H5BN2O2
Molecular Weight	123.91 g/mol
Synonyms	5-Pyrimidineboronic Acid; (Pyrimidin-5-yl)boronic Acid; 5-Boronopyrimidine; Pyrimidin-5-ylboronic Acid; 5-Pyrimidylboronic Acid; 1446-27-1; Pyrimidine-5-yl-B(OH)2
EINECS	Contact for details

Quality Control

Our Pyrimidine-5-Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for sensitive coupling reactions. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment. We support cGMP compliance for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) to prevent oxidation and hydrolysis. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Assay (NMR)	≥95.0%
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.