Description

(1S,βs)-1,4,4Aα,5,6,7,8,8A-Octahydro-β,2,5,5,8Aβ-Pentamethyl-4-Oxo-1β-Naphthalenepentanoic Acid Methyl Ester is a high-purity, complex organic ester with a defined stereochemistry, serving as a critical advanced intermediate in fine chemical synthesis. Its precise molecular architecture makes it valuable for constructing complex pharmacophores and specialty compounds where structural integrity is paramount. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material sectors seeking reliable, high-quality building blocks.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of novel therapeutic agents, particularly in steroid-like or complex tricyclic frameworks.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and plant growth regulators requiring specific stereochemical configurations.
• Fine Chemical Production: Serves as a precursor for fragrances, flavors, and other high-value specialty chemicals where purity is critical.
• Academic & Industrial Research: A valuable reference standard and starting material in organic chemistry research for methodology development and total synthesis projects.
• Material Science: Potential intermediate in the development of specialty polymers or liquid crystals with specific optical properties.

Basic Information

Product Name	(1S,βs)-1,4,4Aα,5,6,7,8,8A-Octahydro-β,2,5,5,8Aβ-Pentamethyl-4-Oxo-1β-Naphthalenepentanoic Acid Methyl Ester
CAS No.	1438-56-8
Molecular Formula	C21H34O3
Molecular Weight	334.50 g/mol
Synonyms	Methyl (1S,4aS,8aR)-1,4a,5,6,7,8,8a,9-Octahydro-2,5,5,8a-tetramethyl-4-oxo-1-naphthalenepentanoate; Methyl 3-[(1S,4aS,8aR)-5,5,8a-Trimethyl-2-methylidene-4-oxo-3,4,4a,5,6,7,8,8a-octahydro-1H-naphthalen-1-yl]butanoate; Ambretone; Amberketone; (1S,4aS,8aR)-1,4a,5,6,7,8,8a,9-Octahydro-2,5,5,8a-tetramethyl-4-oxo-1-naphthalenepentanoic Acid Methyl Ester; Methyl Ambretate; Amber Fragrance Ketone Ester
EINECS	Contact for details

Quality Control

Every batch of our (1S,βs)-1,4,4Aα,5,6,7,8,8A-Octahydro-β,2,5,5,8Aβ-Pentamethyl-4-Oxo-1β-Naphthalenepentanoic Acid Methyl Ester is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, GC, NMR, and optical rotation measurements. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product should be kept under an inert atmosphere for long-term storage to maintain stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]20/D	Specific range provided on COA
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.