Description

3,5-Difluorochlorobenzene is a high-purity fluorinated aromatic building block essential for advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials, where its unique substitution pattern enables precise molecular design. It is critically needed by R&D chemists and process development teams in the pharmaceutical, agrochemical, and liquid crystal industries seeking to introduce fluorine and chlorine functionalities into complex molecules.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel drug candidates, particularly in kinase inhibitors and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the manufacturing of advanced herbicides, fungicides, and pesticides that require fluorinated aromatic cores for enhanced bioactivity and environmental stability.
• Liquid Crystal Materials: Serves as a building block for fluorinated liquid crystal molecules used in high-performance displays (LCDs).
• Organic Electronics: Employed in the research and development of organic semiconductors and electro-optical materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Fluorine Chemistry Research: A valuable reagent for studying nucleophilic aromatic substitution and other reactions specific to difluorinated arenes.

Basic Information

Product Name	3,5-Difluorochlorobenzene
CAS No.	1435-43-4
Molecular Formula	C6H3ClF2
Molecular Weight	148.54 g/mol
Synonyms	1-Chloro-3,5-difluorobenzene; 3,5-Difluorophenyl chloride; Benzene, 1-chloro-3,5-difluoro-; 3,5-Difluorochlorobenzol; 3,5-DFCB; Chloro-3,5-difluorobenzene
EINECS	Contact for details

Quality Control

Our 3,5-Difluorochlorobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing including GC, HPLC, and NMR to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for your most demanding synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.