Description

Colocynthin is a bitter-tasting, highly potent cucurbitacin triterpenoid compound derived from the fruit of the *Citrullus colocynthis* plant. This natural product is of significant interest for its potent biological activity, serving as a key reference standard and active ingredient in research and development. It is primarily sought by professionals in the pharmaceutical, nutraceutical, and botanical extract industries for applications in analytical research, phytochemical studies, and the development of specialized formulations.

Application

• As a primary reference standard for the quality control and standardization of colocynth extracts and related botanical products.
• In phytochemical and pharmacological research to study its bioactivity, mechanism of action, and potential therapeutic applications.
• For use in analytical method development and validation in HPLC, LC-MS, and TLC protocols within quality control laboratories.
• As a key marker compound in the manufacture of standardized herbal extracts and dietary supplements.
• In academic and institutional research exploring natural product chemistry and structure-activity relationships (SAR).
• For the formulation of specialized research chemicals and biochemical reagents.

Basic Information

Product Name	Colocynthin
CAS No.	1398-78-3
Molecular Formula	C56H86O24
Molecular Weight	1119.27 g/mol
Synonyms	α-Elaterin; Citrullin; Colocynthein; Cucurbitacin E 2-O-β-D-glucopyranoside; 2-(β-D-Glucopyranosyloxy)-16,20-dihydroxy-9-methyl-19-norlanosta-1,5,23-triene-3,11,22-trione; (23E)-25-Acetoxy-2-(β-D-glucopyranosyloxy)-3,16,20-trihydroxy-9-methyl-19-nor-9β-lanosta-1,5,23-triene-11,22-dione
EINECS	Contact for details

Quality Control

Our Colocynthin is produced and handled under strict quality management protocols. Each batch undergoes rigorous identity, purity, and potency testing using advanced analytical techniques such as HPLC and NMR to ensure it meets stringent specifications for research and industrial use. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Solubility	Soluble in methanol, DMSO; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.