Description

4-(Allyloxy)-1-Bromo-2-(Trifluoromethyl)Benzene is a specialized halogenated aromatic building block of significant interest in advanced organic synthesis. Its molecular architecture, featuring a reactive bromine atom, a trifluoromethyl group, and an allyloxy ether, makes it a versatile precursor for constructing complex molecules. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in cross-coupling reactions, fluorinated compound synthesis, and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for introducing the trifluoromethyl group and aryl-bromide functionality for further derivatization.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and insecticides where the unique properties of fluorine atoms enhance biological activity and environmental stability.
• Material Science Research: Serves as a monomer or precursor for synthesizing specialty polymers, liquid crystals, and advanced organic electronic materials.
• Cross-Coupling Reactions: The aryl bromide moiety is an excellent substrate for palladium-catalyzed reactions like Suzuki, Heck, and Sonogashira couplings to form complex biaryl and other structures.
• Fluorinated Compound Libraries: Essential for medicinal chemistry programs focused on building diverse screening libraries containing the metabolically stable trifluoromethyl group.
• Ligand and Catalyst Development: The allyloxy group can be modified or used to anchor metal complexes, aiding in the development of new catalytic systems.

Basic Information

Product Name	4-(Allyloxy)-1-Bromo-2-(Trifluoromethyl)Benzene
CAS No.	1208-41-9
Molecular Formula	C10H8BrF3O
Molecular Weight	281.07 g/mol
Synonyms	1-Bromo-4-(allyloxy)-2-(trifluoromethyl)benzene; 2-Bromo-5-(allyloxy)benzotrifluoride; 4-Allyloxy-2-trifluoromethylbromobenzene; 4-Bromo-3-(trifluoromethyl)phenyl allyl ether; 1-Bromo-2-trifluoromethyl-4-allyloxybenzene; Benzene, 1-bromo-4-(2-propen-1-yloxy)-2-(trifluoromethyl)-; 2-Trifluoromethyl-4-allyloxybromobenzene
EINECS	Contact for details

Quality Control

Our 4-(Allyloxy)-1-Bromo-2-(Trifluoromethyl)Benzene is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity for research and development applications. We employ advanced analytical techniques including GC, HPLC, and NMR to verify identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated place away from heat and ignition sources. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use to prevent evaporation and concentration changes. Recommended storage temperature is between 2°C and 8°C for long-term stability, though short-term storage at controlled room temperature (15-25°C) is acceptable.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	~1.55 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.