Description

(2S)-1,1-Dimethyl-2,3,4,5-Tetrahydropyrrole-2-Carboxylate is a high-purity chiral building block and intermediate of significant interest in advanced organic synthesis. Its value lies in its rigid pyrrolidine structure, which serves as a key scaffold for constructing complex molecules with defined stereochemistry. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly where precise three-dimensional structure is critical for biological activity.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) drugs and other therapeutics requiring specific stereochemistry.
• Agrochemical Synthesis: Used as a building block for creating novel pesticides and herbicides with enhanced efficacy and selectivity.
• Catalyst and Ligand Development: Serves as a starting material for synthesizing chiral catalysts and ligands used in asymmetric synthesis.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances where the pyrrolidine core structure is required.
• Academic and R&D: A valuable compound for research institutions conducting studies in medicinal chemistry, synthetic methodology, and material science.
• Peptidomimetics: The structure is utilized in the design and synthesis of peptidomimetics, which are molecules that mimic peptides for drug discovery.

Basic Information

Product Name	(2S)-1,1-Dimethyl-2,3,4,5-Tetrahydropyrrole-2-Carboxylate
CAS No.	1195-94-4
Molecular Formula	C8H15NO2
Molecular Weight	157.21 g/mol
Synonyms	L-Proline, 1,1-dimethyl-, methyl ester; Methyl 1,1-dimethyl-L-prolinate; (S)-1,1-Dimethylpyrrolidine-2-carboxylic acid methyl ester; (2S)-1,1-Dimethylpyrrolidine-2-carboxylate; Methyl (2S)-1,1-dimethyl-2,3,4,5-tetrahydropyrrole-2-carboxylate; 1,1-Dimethyl-L-proline methyl ester; (S)-(-)-1,1-Dimethyl-2-pyrrolidinecarboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our (2S)-1,1-Dimethyl-2,3,4,5-Tetrahydropyrrole-2-Carboxylate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.