Description

3-(Chloromethyl)-5-Methyl-1,2,4-Oxadiazole is a versatile heterocyclic building block characterized by its reactive chloromethyl group fused to a 1,2,4-oxadiazole ring. This compound matters as a key synthetic intermediate for constructing more complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for lead optimization and scalable synthesis.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block for the synthesis of novel drug candidates, particularly those containing the 1,2,4-oxadiazole pharmacophore, which is associated with a range of biological activities.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides, where the oxadiazole ring contributes to biological efficacy.
• Material Science Research: Employed in the development of specialty polymers, ligands, and functional materials that require specific heterocyclic components.
• Chemical Biology & Proteomics: Acts as a reactive handle in the design of chemical probes, activity-based probes, and linker molecules for studying biological systems.
• Cross-Coupling Reactions: The chloromethyl group can be utilized in various palladium-catalyzed or other metal-mediated coupling reactions to form carbon-carbon bonds.
• Nucleophilic Substitution Scaffold: Provides a reactive site for substitution with various nucleophiles (amines, thiols, alkoxides) to create diverse chemical libraries.

Basic Information

Product Name	3-(Chloromethyl)-5-Methyl-1,2,4-Oxadiazole
CAS No.	1192-80-9
Molecular Formula	C4H5ClN2O
Molecular Weight	132.55 g/mol
Synonyms	5-Methyl-3-(chloromethyl)-1,2,4-oxadiazole; 3-Chloromethyl-5-methyl-1,2,4-oxadiazole; 1,2,4-Oxadiazole, 3-(chloromethyl)-5-methyl-; 5-Methyl-3-oxadiazolemethyl chloride; NSC 403697
EINECS	214-761-5

Quality Control

Every batch of 3-(Chloromethyl)-5-Methyl-1,2,4-Oxadiazole undergoes rigorous analytical testing to ensure it meets the high-purity standards required for research and synthesis. Our quality control protocols are designed to guarantee batch-to-batch consistency and reliability. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container must be kept tightly closed to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.