Description

5-(1,3-Dioxo-1,3-Dihydro-Isoindol-2-Yl)-Pentanoic Acid CAS NO 1147-76-8 is a high-purity organic compound featuring a phthalimide moiety linked to a pentanoic acid chain, serving as a versatile and critical building block in advanced chemical synthesis. Its primary value lies in its role as a key intermediate for the production of pharmaceuticals, agrochemicals, and functional materials, where precise molecular structure is paramount. This product is essential for research institutions, fine chemical manufacturers, and pharmaceutical companies engaged in developing new active ingredients and specialty polymers.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting neurological and inflammatory pathways.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and plant growth regulators.
• Polymer & Material Science: Serves as a monomer or cross-linking agent for creating specialized polyimides, coatings, and adhesives with enhanced thermal stability.
• Bioconjugation & Linker Chemistry: The reactive carboxylic acid and imide groups make it suitable for creating cleavable linkers in antibody-drug conjugates (ADCs) and proteolysis-targeting chimeras (PROTACs).
• Organic Synthesis Reagent: Employed in academic and industrial R&D for constructing complex heterocyclic compounds and as a protecting group strategy.
• Dye & Pigment Manufacturing: Acts as an intermediate in the production of high-performance pigments and optical brighteners.

Basic Information

Product Name	5-(1,3-Dioxo-1,3-Dihydro-Isoindol-2-Yl)-Pentanoic Acid
CAS No.	1147-76-8
Molecular Formula	C13H13NO4
Molecular Weight	247.25 g/mol
Synonyms	2-(4-Carboxybutyl)isoindoline-1,3-dione; 5-Phthalimidopentanoic Acid; 5-(1,3-Dioxoisoindolin-2-yl)pentanoic Acid; N-(4-Carboxybutyl)phthalimide; 4-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)butanoic Acid (alternative numbering); Phthalimide-N-pentanoic Acid; 2-(5-Carboxypentyl)isoindole-1,3-dione; GLPG-XXXX (example research code)
EINECS	Contact for details

Quality Control

Our 5-(1,3-Dioxo-1,3-Dihydro-Isoindol-2-Yl)-Pentanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Production can be aligned with cGMP standards for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); keep the container tightly sealed when not in use to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.