Description

(1E,3E)-1,3-Butadiene-1,4-Dicarboxylic Acid Dimethyl Ester is a high-purity, conjugated diene diester that serves as a versatile and critical building block in advanced organic synthesis. Its primary value lies in its role as a key dienophile in Diels-Alder reactions and as a precursor for the synthesis of complex cyclic and heterocyclic compounds. This intermediate is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality raw materials for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for constructing complex carbocyclic and heterocyclic ring systems via cycloaddition reactions.
• Agrochemical Synthesis: Used in the production of advanced crop protection agents, where its diene structure enables the creation of specific, bioactive molecular frameworks.
• Polymer & Material Science: Acts as a monomer or co-monomer in the development of specialty polymers with tailored properties, such as those with conjugated backbones for electronic applications.
• Organic Synthesis & R&D: A fundamental reagent in academic and industrial research laboratories for exploring new synthetic methodologies, particularly in pericyclic and cascade reactions.
• Fine Chemical Production: Employed in the manufacture of complex fragrances, flavors, and other high-value fine chemicals where precise stereochemistry is required.

Basic Information

Product Name	(1E,3E)-1,3-Butadiene-1,4-Dicarboxylic Acid Dimethyl Ester
CAS No.	1119-43-3
Molecular Formula	C8H10O4
Molecular Weight	170.16 g/mol
Synonyms	Dimethyl (1E,3E)-1,3-Butadiene-1,4-dicarboxylate; (E,E)-Muconic Acid Dimethyl Ester; trans,trans-Dimethyl Muconate; Dimethyl trans,trans-Muconate; (1E,3E)-Muconic Acid Dimethyl Ester; 2,4-Hexadienedioic Acid, Dimethyl Ester, (E,E)-; DMAD (in specific contexts); Butadiene-1,4-dicarboxylic Acid Dimethyl Ester
EINECS	214-277-4

Quality Control

Our (1E,3E)-1,3-Butadiene-1,4-Dicarboxylic Acid Dimethyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical documentation, including Certificates of Analysis (COA) with detailed results from GC, HPLC, and NMR analyses. Our quality commitment aligns with cGMP principles where applicable, ensuring the material meets the stringent requirements for use as a pharmaceutical intermediate.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light) and should be handled under an inert atmosphere for long-term storage to prevent potential oxidation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.