Description

5-Methyloxazolidin-2-One is a versatile heterocyclic building block and chiral auxiliary of significant importance in modern synthetic chemistry. Its value lies in its ability to impart stereochemical control in asymmetric synthesis, enabling the production of high-purity enantiomerically enriched compounds. This product is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality intermediates for complex molecule synthesis.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of antibiotics and other bioactive molecules.
• Asymmetric Synthesis Auxiliary: Used as a chiral controller in Evans-type aldol reactions and other stereoselective transformations to construct complex molecular architectures.
• Agrochemical Research: Serves as a building block for developing novel, enantiomerically pure herbicides, fungicides, and insecticides.
• Ligand and Catalyst Preparation: A precursor for synthesizing specialized ligands and organocatalysts used in homogeneous catalysis.
• Peptidomimetics and Protease Inhibitors: Incorporated into the backbone of peptide analogs to enhance stability and biological activity.
• Academic and R&D Laboratories: A fundamental reagent for methodological development in organic and medicinal chemistry research.

Basic Information

Product Name	5-Methyloxazolidin-2-One
CAS No.	1072-70-4
Molecular Formula	C4H7NO2
Molecular Weight	101.10 g/mol
Synonyms	5-Methyl-2-oxazolidinone; (S)-(-)-5-Methyl-2-oxazolidinone; (R)-(+)-5-Methyl-2-oxazolidinone; Evans Auxiliary; (4S)-5-Methyloxazolidin-2-one; (4R)-5-Methyloxazolidin-2-one; 2-Oxazolidinone, 5-methyl-; L-5-Methyl-2-oxazolidinone; D-5-Methyl-2-oxazolidinone
EINECS	213-999-1

Quality Control

Our 5-Methyloxazolidin-2-One is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including chiral purity (enantiomeric excess) and standard impurity profiles. A detailed Certificate of Analysis (COA) is supplied with each batch, confirming compliance with customer specifications and relevant industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (ee)	≥ 99.0% (for enantiomerically pure grades)
Melting Point	86 - 90 °C
Loss on Drying	≤ 0.5 %
Residue on Ignition	≤ 0.1 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.