Description

3-(Aminooxy)-1-Propanethiol Hydrochloride is a specialized bifunctional organic compound that serves as a versatile building block in advanced synthesis. Its unique structure, featuring both an aminooxy and a thiol group, makes it a critical reagent for conjugation and cross-linking applications, enabling the creation of stable, site-specific linkages. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and bioconjugation sectors who require reliable, high-quality materials for developing novel therapeutics and diagnostic agents.

Application

• Bioconjugation Reagent: Used for the site-specific modification of proteins, antibodies, and peptides via oxime ligation or thiol-based coupling.
• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of complex drug molecules, particularly those requiring stable linker chemistry.
• Cross-linking Agent: Employed in material science and polymer chemistry to create hydrogels, networks, and functionalized surfaces.
• Surface Functionalization: Used to modify gold nanoparticles, biosensors, and other substrates through its thiol group for enhanced biocompatibility or targeting.
• Chemical Biology Tool: Facilitates the study of biomolecular interactions and the development of activity-based probes.
• Antibody-Drug Conjugate (ADC) Development: Acts as a potential linker component for connecting cytotoxic payloads to monoclonal antibodies.

Basic Information

Product Name	3-(Aminooxy)-1-Propanethiol Hydrochloride
CAS No.	1071-99-4
Molecular Formula	C3H10ClNOS
Molecular Weight	143.63 g/mol
Synonyms	3-(Aminooxy)propane-1-thiol Hydrochloride; 1-Propanethiol, 3-(aminooxy)-, hydrochloride; 3-Aminoxypropanethiol HCl; 3-Mercaptopropylaminooxy Hydrochloride; O-(3-Mercaptopropyl)hydroxylamine Hydrochloride; Aminooxypropylthiol HCl; APT-HCl; 3-APT·HCl
EINECS	Contact for details

Quality Control

Our 3-(Aminooxy)-1-Propanethiol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and titration, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, assay, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opened to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.