Alkylating Antineoplastic Agents

Antineoplastics

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Alkylating Antineoplastic Agents

Alkylating antineoplastic agents are cytotoxic APIs that form covalent bonds with DNA, leading to cross-linking, strand breaks, and inhibition of replication and transcription. This class includes nitrogen mustards, nitrosoureas, alkyl sulfonates, triazenes, and platinum-based drugs. They are effective against a wide range of hematologic malignancies and solid tumors such as breast cancer, ovarian cancer, sarcomas, and brain tumors. Their mechanism is cell cycle–nonspecific, making them particularly active against rapidly dividing cells. However, their strong cytotoxicity can result in bone marrow suppression, infertility, and secondary malignancies. Despite these risks, alkylating agents remain foundational drugs in many chemotherapeutic regimens due to their broad antitumor activity.

n-(2-Chloroethyl)-n-Nitrosocarbamoylvalinamide CAS NO 81965-44-8

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CAS No.:81965-44-8

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Content:99.90%

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Bis(Glutathionato)Platinum(Ii) CAS NO 81998-39-2

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CAS No.:81998-39-2

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4-(3,3-Dimethyltriazeno)-5-Nitroimidazole CAS NO 82039-94-9

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CAS No.:82039-94-9

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Ditiomustine CAS NO 82599-22-2

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CAS No.:82599-22-2

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Diamminechloro(Guanosine-N(7))Platinum(Ii) CAS NO 82758-00-7

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CAS No.:82758-00-7

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Β-D-Fructofuranosyl 6-[[[(2-Chloroethyl)Nitrosoamino]Carbonyl]Amino]-6-Deoxy-Α-D-Glucopyranoside CAS NO 83009-11-4

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CAS No.:83009-11-4

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Dichloroglycineuracil Platinum(Ii) CAS NO 83126-99-2

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CAS No.:83126-99-2

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Chloromethylketone Methotrexate CAS NO 83160-47-8

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CAS No.:83160-47-8

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