Other β-Lactams
Other β-Lactams
Other β-lactams encompass non-penicillin and non-cephalosporin β-lactam antibiotics such as carbapenems and monobactams. These agents inhibit bacterial cell wall synthesis by binding to penicillin-binding proteins, resulting in rapid bactericidal activity. Carbapenems, including imipenem, meropenem, and ertapenem, are among the broadest-spectrum antibiotics available and are essential for multidrug-resistant infections. Monobactams like aztreonam offer selective Gram-negative coverage and can be used safely in patients with penicillin allergies. These β-lactams are commonly employed for complicated intra-abdominal infections, sepsis, hospital-acquired pneumonia, and resistant urinary tract infections. Their stability against many β-lactamases makes them frontline agents in critical care settings.
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