Description

Dichloro{(R)-(+)-5,5'-bis[di(3,5-xylyl)phosphino]-4,4'-bi-1,3-benzodioxole}[(2R)-(-)-1,1-bis(4-methoxyphenyl)-3-methyl-1,2-butanediamine]ruthenium(II), commonly referred to as RuCl2[(R)-dm-segphos][(R)-daipen], is a highly specialized, chiral ruthenium complex designed for asymmetric hydrogenation and other enantioselective catalytic transformations. This compound is critical for achieving high enantiomeric excess (ee) in the synthesis of complex pharmaceutical intermediates and fine chemicals. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemical control.

Application

• Asymmetric Hydrogenation Catalyst: For the enantioselective reduction of ketones, imines, and functionalized olefins in pharmaceutical intermediate synthesis.
• Pharmaceutical Manufacturing: Production of chiral active pharmaceutical ingredients (APIs) for drugs targeting central nervous system disorders, cardiovascular diseases, and anti-infectives.
• Agrochemical Synthesis: Creation of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Fine Chemical Production: Synthesis of chiral ligands, flavors, fragrances, and advanced organic materials.
• Academic & Industrial Research: A key reagent for developing new catalytic methodologies and exploring novel reaction pathways in asymmetric synthesis.
• Process Chemistry Optimization: Scaling up enantioselective reactions from laboratory to pilot plant and commercial production.

Basic Information

Product Name	Dichloro{(R)-(+)-5,5'-bis[di(3,5-xylyl)phosphino]-4,4'-bi-1,3-benzodioxole}[(2R)-(-)-1,1-bis(4-methoxyphenyl)-3-methyl-1,2-butanediamine]ruthenium(II)
CAS No.	944450-43-5
Molecular Formula	C78H78Cl2NO6P2Ru
Molecular Weight	1368.84 g/mol
Synonyms	RuCl2[(R)-dm-segphos][(R)-daipen]; Dichloro[(R)-5,5'-bis[di(3,5-xylyl)phosphino]-4,4'-bi-1,3-benzodioxole][(2R)-1,1-bis(4-methoxyphenyl)-3-methyl-1,2-butanediamine]ruthenium; Ruthenium(II) dichloride (R)-dm-segphos (R)-daipen complex; (R,R)-RuCl2(daipen)(dm-segphos); Asymmetric Hydrogenation Catalyst Ru-dm-segphos-daipen; Chiral Ruthenium Diphosphine Diamine Complex
EINECS	Contact for details

Quality Control

Every batch of this high-value chiral catalyst is produced and tested under strict inert atmosphere conditions to prevent oxidation and ensure catalytic activity. Our quality assurance protocol includes comprehensive analytical characterization to verify identity, chiral purity, and metal content. Certificates of Analysis (COA) are provided with each shipment, detailing specifications such as assay by HPLC/NMR, enantiomeric excess, and residual solvent levels, ensuring compliance with rigorous R&D and cGMP standards for advanced synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the product under an inert atmosphere (argon or nitrogen) at 2-8°C. The container should be kept in a cool, dry, and well-ventilated area, separate from incompatible materials. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Orange to red-brown crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Ruthenium Content	7.0 - 7.8%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.