Description

Grubbs Catalyst 2nd Generation is a highly active, ruthenium-based metathesis catalyst widely recognized for its superior stability and functional group tolerance compared to earlier generations. This compound is essential for enabling efficient and selective carbon-carbon double bond formation, a cornerstone reaction in modern synthetic chemistry. It is a critical reagent for R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors, facilitating the synthesis of complex molecules and polymers.

Application

• Pharmaceutical Intermediate Synthesis: Key for constructing complex ring systems and macrocycles via ring-closing metathesis (RCM).
• Polymer & Material Science: Enables the production of specialty polymers through ring-opening metathesis polymerization (ROMP) and acyclic diene metathesis (ADMET).
• Agrochemical Research: Used in the development of novel active ingredients with specific stereochemistry.
• Fine Chemical Manufacturing: Facilitates cross-metathesis reactions for the efficient synthesis of olefinic building blocks.
• Academic & Industrial R&D: A staple catalyst for methodology development and exploring new synthetic pathways.
• Cross-Coupling & Tandem Catalysis: Employed in sophisticated multi-step, one-pot synthetic sequences.

Basic Information

Product Name	Grubbs Catalyst 2nd Generation
CAS No.	246047-72-3
Molecular Formula	C46H65Cl2N2PRu
Molecular Weight	848.96 g/mol
Synonyms	Benzylidene[1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro(tricyclohexylphosphine)ruthenium; Grubbs II Catalyst; Grubbs Catalyst Second Generation; (H2IMes)(PCy3)(Cl)2Ru=CHPh; RuCl2(=CHPh)(IMesH2)(PCy3); 2nd Gen Grubbs Catalyst
EINECS	Contact for details

Quality Control

Our Grubbs Catalyst 2nd Generation is manufactured under stringent quality protocols. Each batch undergoes comprehensive analytical testing, including NMR, HPLC, and elemental analysis, to ensure high purity and catalytic activity consistent with leading research standards. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability and batch-to-batch consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to maintain stability and prevent decomposition. This material is easily oxidized and light-sensitive; prolonged exposure to air, moisture, or ambient light should be avoided.

Specification

Item	Specification
Appearance	Purple to brown crystalline solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97%
Solubility	Soluble in common organic solvents (DCM, toluene, THF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.