Description

(Z)-4-Hydroxy-2-methyl-2-butenoic acid [(1aR,3S,4Z,5aR,8aR,9R,10aR)-3-acetoxy-1a,2,3,5a,7,8,8a,9,10,10a-decahydro-4,10a-dimethyl-8-methylene-7-oxooxireno[5,6]cyclodeca[1,2-b]furan-9-yl] ester is a high-purity, complex organic ester with significant potential in advanced chemical synthesis. This compound is valued for its intricate stereochemistry and functional groups, making it a critical chiral building block for the development of novel active molecules. It is primarily sought by research institutions and industrial R&D departments in the pharmaceutical, agrochemical, and specialty chemical sectors for applications requiring precise molecular architecture.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for complex therapeutic agents.
• Agrochemical Research: Used as a precursor in the synthesis of novel pesticides, herbicides, or plant growth regulators with specific stereochemical requirements.
• Advanced Material Synthesis: Acts as a monomer or functionalizing agent in the creation of specialty polymers and materials with tailored properties.
• Chemical Biology Probe Development: Employed in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Process Chemistry & Scale-Up: Provides a defined, high-quality starting material for process optimization and pilot-scale production runs in fine chemical manufacturing.
• Academic & Institutional Research: Utilized in university and government laboratories for fundamental studies in organic synthesis, catalysis, and medicinal chemistry.

Basic Information

Item	Details
Product Name	(Z)-4-Hydroxy-2-methyl-2-butenoic acid [(1aR,3S,4Z,5aR,8aR,9R,10aR)-3-acetoxy-1a,2,3,5a,7,8,8a,9,10,10a-decahydro-4,10a-dimethyl-8-methylene-7-oxooxireno[5,6]cyclodeca[1,2-b]furan-9-yl] ester
CAS No.	72947-93-4
Molecular Formula	C22H28O8
Molecular Weight	420.46 g/mol
Synonyms	Artemisitene; (3R,5aS,6R,8aS,9R,10S,12R,12aR)-10-Ethenyldecahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-ol 4-acetoxy-2-methyl-2-butenoate; 4-Acetoxy-2-methyl-2-butenoic acid (1aR,3S,4Z,5aR,8aR,9R,10aR)-3-acetoxy-1a,2,3,5a,7,8,8a,9,10,10a-decahydro-4,10a-dimethyl-8-methylene-7-oxooxireno[5,6]cyclodeca[1,2-b]furan-9-yl ester; Dihydroartemisinin acetate crotonate; Arteannuin B derivative
EINECS	Contact for details

Quality Control

Our production of (Z)-4-Hydroxy-2-methyl-2-butenoic acid ester (CAS 72947-93-4) adheres to stringent quality management protocols to ensure batch-to-batch consistency and purity. The material is characterized using advanced analytical techniques including HPLC, NMR, and MS to confirm identity, chiral purity, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment, supporting compliance in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) to minimize oxidation. Keep the container in a cool, dry, and well-ventilated area separate from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.