Description

3-Methyl-2-butenoic acid [(1aR,4E,6R,7R,7aR,10aS,10bR)-1a,2,3,6,7,7a,8,9,10a,10b-decahydro-6-hydroxy-1a,5-dimethyl-8-methylene-9-oxooxireno[9,10]cyclodeca[1,2-b]furan-7-yl] ester is a high-purity, complex organic ester derivative of a furan-containing sesquiterpene lactone. This compound is valued for its role as a key synthetic intermediate and reference standard in advanced organic synthesis and pharmaceutical research. It is primarily utilized by research institutions and industrial R&D departments focused on developing novel therapeutic agents, particularly in the fields of oncology and anti-inflammatory drug discovery.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of complex natural product analogs and novel drug candidates.
• Reference Standard: Used for analytical method development, validation, and quality control in pharmaceutical laboratories.
• Medicinal Chemistry Research: A valuable scaffold for structure-activity relationship (SAR) studies to explore new bioactive molecules.
• Academic Research: Employed in university and institutional labs for studying chemical synthesis pathways and reaction mechanisms of sesquiterpene derivatives.
• Process Development: Supports scale-up and optimization studies for the production of target active pharmaceutical ingredients (APIs).

Basic Information

Product Name	3-Methyl-2-butenoic acid [(1aR,4E,6R,7R,7aR,10aS,10bR)-1a,2,3,6,7,7a,8,9,10a,10b-decahydro-6-hydroxy-1a,5-dimethyl-8-methylene-9-oxooxireno[9,10]cyclodeca[1,2-b]furan-7-yl] ester
CAS No.	61264-10-6
Molecular Formula	C21H26O6
Molecular Weight	374.43 g/mol
Synonyms	3,3-Dimethylacrylic acid, (1aR,4E,6R,7R,7aR,10aS,10bR)-1a,2,3,6,7,7a,8,9,10a,10b-decahydro-6-hydroxy-1a,5-dimethyl-8-methylene-9-oxooxireno[9,10]cyclodeca[1,2-b]furan-7-yl ester; 3-Methylbut-2-enoic acid sesquiterpene lactone ester; Parthenolide 3,3-dimethylacrylate; Parthenolide 3-methyl-2-butenoate; (1aR,4E,6R,7R,7aR,10aS,10bR)-7-[(3-Methylbut-2-enoyl)oxy]-1a,5-dimethyl-8-methylidene-9-oxo-1a,2,3,6,7,7a,8,9,10a,10b-decahydrooxireno[9,10]cyclodeca[1,2-b]furan-6-ol
EINECS	Contact for details

Quality Control

Our 3-Methyl-2-butenoic acid [(1aR,4E,6R,7R,7aR,10aS,10bR)-1a,2,3,6,7,7a,8,9,10a,10b-decahydro-6-hydroxy-1a,5-dimethyl-8-methylene-9-oxooxireno[9,10]cyclodeca[1,2-b]furan-7-yl] ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. The compound may be sensitive to prolonged exposure to heat and moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0% Any single impurity ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.