Description

Palladium, [2-[2-(amino-κN)ethyl]phenyl-κC][[2',6'-bis(1-methylethoxy)[1,1'-biphenyl]-2-yl]dicyclohexylphosphine-κP]chloro-, (SP-4-4)-, compd. with 2-methoxy-2-methylpropane (1:1) is a sophisticated, single-component palladium precatalyst designed for high-performance cross-coupling reactions. This compound matters because it offers exceptional air stability and ease of handling compared to sensitive in-situ catalyst systems, enabling more reproducible and scalable synthetic processes. It is primarily needed by pharmaceutical R&D and process chemistry teams for constructing complex molecular architectures, such as APIs and advanced intermediates, through Buchwald-Hartwig amination and related C–N, C–O bond-forming reactions.

Application

• Pharmaceutical Intermediate Synthesis: A key catalyst for Buchwald-Hartwig amination in the production of active pharmaceutical ingredients (APIs) and advanced drug candidates.
• Cross-Coupling Reactions: Enables efficient C–N and C–O bond formation for constructing complex, functionalized (hetero)aryl amines and ethers.
• Process Chemistry & Scale-Up: Ideal for transitioning from laboratory discovery to pilot plant and commercial manufacturing due to its stability and consistent performance.
• Ligand-Accelerated Catalysis: Serves as a precatalyst featuring the sterically demanding and electron-rich BippyPhos ligand system for challenging substrates.
• Material Science Research: Used in the synthesis of organic electronic materials and specialty polymers requiring precise palladium-catalyzed couplings.
• Agrochemical Synthesis: Applied in the development of novel herbicides, fungicides, and insecticides that contain aryl amine motifs.

Basic Information

Item	Details
Product Name	Palladium, [2-[2-(amino-κN)ethyl]phenyl-κC][[2',6'-bis(1-methylethoxy)[1,1'-biphenyl]-2-yl]dicyclohexylphosphine-κP]chloro-, (SP-4-4)-, compd. with 2-methoxy-2-methylpropane (1:1)
CAS No.	2361069-97-6
Molecular Formula	C48H71ClNO3PPd
Molecular Weight	883.88 g/mol
Synonyms	BippyPhos Palladium Precatalyst; Chloro(2-(2-aminoethyl)phenyl-C,N)[2',6'-bis(isopropoxy)[1,1'-biphenyl]-2-yl]dicyclohexylphosphine-P]palladium; Palladium(II) BippyPhos Aminobenzyl Complex; Pd(BippyPhos)(o-amidobenzyl)Cl; (SP-4-4)-Chloro[2-[2-(amino-κN)ethyl]phenyl-κC][[2',6'-bis(1-methylethoxy)[1,1'-biphenyl]-2-yl]dicyclohexylphosphine-κP]palladium; Buchwald-Hartwig Catalyst Precursor; CAS 2361069-97-6
EINECS	Contact for details

Quality Control

Our palladium precatalyst is manufactured under strict quality protocols to ensure batch-to-batch consistency and high catalytic activity. Each lot undergoes comprehensive analysis, including NMR, HPLC, and elemental analysis, to verify identity, purity, and the absence of deleterious impurities. Certificates of Analysis (COA) with full analytical data are provided to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to maintain long-term stability. The compound is sensitive to moisture and oxygen; allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Yellow to orange crystalline solid or powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay (Pd content)	11.5 - 12.5 %
Solubility	Soluble in common organic solvents (DCM, THF, toluene)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.