Description

Methanesulfonato(2-bis(3,5-di(trifluoromethyl)phenylphosphino)-3,6-dimethoxy-2',6'-bis(dimethylamino)-1,1'-biphenyl )(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II) is a highly specialized, air-stable palladium(II) precatalyst designed for demanding cross-coupling reactions. Its sophisticated ligand architecture provides exceptional activity and selectivity, enabling efficient synthesis of complex molecules under mild conditions. This catalyst is essential for advanced pharmaceutical research and fine chemical manufacturing, particularly in the synthesis of active pharmaceutical ingredients (APIs) and novel organic materials.

Application

• Pharmaceutical Intermediate Synthesis: A key catalyst for Buchwald-Hartwig amination, Suzuki-Miyaura, and other C-N/C-C cross-coupling reactions in API development.
• Fine Chemical Production: Enables the efficient and selective construction of complex, functionalized biaryl and heteroaryl structures.
• Academic & Industrial R&D: Used in method development and discovery chemistry for novel compound libraries and material precursors.
• Process Chemistry Optimization: Employed in scaling up coupling reactions due to its stability and predictable performance.
• Material Science: Facilitates the synthesis of conjugated polymers and organic electronic materials requiring precise molecular architecture.

Basic Information

Item	Details
Product Name	Methanesulfonato(2-bis(3,5-di(trifluoromethyl)phenylphosphino)-3,6-dimethoxy-2',6'-bis(dimethylamino)-1,1'-biphenyl )(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II)
CAS No.	1810068-35-9
Molecular Formula	C58H51F12N3O5PPdS
Molecular Weight	~1244.4 g/mol (Contact for details)
Synonyms	Buchwald Palladacycle Precatalyst; G4 Palladacycle Derivative; Methanesulfonato-Buchwald Catalyst; Pd-PEPPSI-type Complex; Palladium(II) Methanesulfonate Complex with Biarylphosphine Ligand; [Pd(AmPhos)(MsO)]; (2-Bis(3,5-di(trifluoromethyl)phenylphosphino)-3,6-dimethoxy-2',6'-bis(dimethylamino)-1,1'-biphenyl)(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II) Methanesulfonate
EINECS	Contact for details

Quality Control

Every batch of our palladium precatalyst undergoes rigorous analytical testing to ensure identity, purity, and catalytic performance. We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing key parameters such as palladium content, ligand-to-metal ratio, and purity by NMR and HPLC. Our quality system is designed to meet the stringent requirements of pharmaceutical R&D and cGMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to maintain long-term stability and prevent decomposition. The product is easily oxidized and should be handled in a controlled, moisture-free environment.

Specification

Item	Specification
Appearance	Orange to red-brown solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Palladium (Pd) Content	7.0 - 9.0 %
Solubility	Soluble in common organic solvents (DCM, THF, Toluene)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.