Description

Bis{[2-(Diadamantylphosphino)-3-methoxy-2,4,6-tri-i-propyl-3-(2,3,5,6-tetrafluoro-4-butylphenyl)-1,1-biphenyl]palladium(0)}1,5-cyclooctadiene, commonly referred to as the AlPhos Palladium complex, is a highly specialized, air-stable palladium catalyst featuring a sterically demanding and electron-rich phosphine ligand. This complex is engineered to enable challenging cross-coupling reactions, particularly for the synthesis of complex pharmaceutical intermediates and advanced materials, where traditional catalysts fail. It is an essential tool for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking robust and selective catalytic solutions.

Application

The AlPhos Palladium complex is a premier catalyst designed for demanding synthetic transformations. Its primary applications include:

• Buchwald-Hartwig Amination: Highly efficient for C–N bond formation, especially with sterically hindered and electronically deactivated aryl halides.
• Suzuki-Miyaura Cross-Coupling: Enables the coupling of aryl chlorides and other challenging substrates with arylboronic acids under mild conditions.
• Pharmaceutical Intermediate Synthesis: Critical for constructing complex, multi-functional molecules in late-stage functionalization for API development.
• Agrochemical Active Ingredient Production: Used in the synthesis of novel herbicides, fungicides, and insecticides requiring selective coupling steps.
• Material Science Research: Facilitates the synthesis of conjugated polymers, organic semiconductors, and liquid crystals.
• Process Chemistry & Scale-Up: Valued for its robustness and consistency in moving reactions from lab-scale to pilot plant and manufacturing.

Basic Information

Product Name	Bis{[2-(Diadamantylphosphino)-3-methoxy-2,4,6-tri-i-propyl-3-(2,3,5,6-tetrafluoro-4-butylphenyl)-1,1-biphenyl]palladium(0)}1,5-cyclooctadiene, [AlPhos Palladium complex]
CAS No.	1805783-51-0
Molecular Formula	C₁₀₈H₁₂₈F₈O₂P₂Pd₂
Molecular Weight	~1990.0 g/mol (Contact for exact details)
Synonyms	AlPhos Pd(0) complex; Bis(AlPhos)palladium(0) 1,5-cyclooctadiene adduct; Palladium(0) bis(2-(di-1-adamantylphosphino)-3',5'-di-tert-butyl-6-methoxy-[1,1'-biphenyl]-2-yl) 1,5-cyclooctadiene; Pd(AlPhos)₂(COD); (AlPhos)₂Pd(COD); Palladium catalyst with AlPhos ligand; Buchwald catalyst AlPhos-Pd(0).
EINECS	Contact for details

Quality Control

Our AlPhos Palladium complex is manufactured under strict quality protocols to ensure batch-to-batch consistency and high catalytic activity. Each lot is characterized by NMR (1H, 31P) and elemental analysis to confirm identity and purity. We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing key specifications such as palladium content, ligand-to-palladium ratio, and solvent residues. Our quality system is designed to meet the stringent requirements of cGMP and ISO 9001 standards for advanced catalytic reagents.

Storage

Preserve in a tightly closed container, protected from light. This material is strictly light-sensitive (protect from all light exposure) and easily oxidized (store under inert atmosphere). For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (NMR)	Conforms to structure
Palladium (Pd) Content	10.5 - 11.0 %
Purity (HPLC)	≥ 95.0%
Solvent Residues (GC)	Meet ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.