Description

L-Ornithinamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-[[[[[(4S)-4,11-diethyl-3,4,12,14-tetrahydro-9-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl]oxy]carbonyl]oxy]methyl]phenyl]- is a sophisticated, high-purity synthetic compound designed for advanced research and development applications. Its complex molecular architecture, featuring a pyrrole-dione linker and a functionalized quinoline-indolizine core, makes it a critical building block for the synthesis of novel bioactive molecules. This product is essential for pharmaceutical and biotechnology organizations focused on drug discovery, particularly in developing targeted therapies and diagnostic agents.

Application

• Pharmaceutical Research & Development (R&D): Serves as a key intermediate in the synthesis of novel small-molecule drug candidates, particularly for oncology and targeted therapies.
• Protease Inhibitor Development: The ornithinamide and valyl components suggest potential utility in designing inhibitors for specific proteolytic enzymes.
• Bioconjugation and Linker Chemistry: The reactive pyrrole-dione (maleimide) moiety enables site-specific conjugation to thiol groups (-SH) on proteins, antibodies, or peptides for creating antibody-drug conjugates (ADCs) or other bioconjugates.
• Chemical Biology Probes: Used to develop molecular probes for studying enzyme function, cellular pathways, and target engagement within biological systems.
• High-Throughput Screening (HTS): Employed as a specialized scaffold in compound libraries to identify new lead structures with desired biological activity.
• Preclinical Studies: Utilized in the synthesis of compounds for pharmacokinetic, pharmacodynamic, and toxicology evaluations.

Basic Information

Product Name	L-Ornithinamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-[[[[[(4S)-4,11-diethyl-3,4,12,14-tetrahydro-9-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl]oxy]carbonyl]oxy]methyl]phenyl]-
CAS No.	1801838-28-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	N-[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-L-ornithinamide derivative; (4S)-4,11-Diethyl-3,4,12,14-tetrahydro-9-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl linked ornithinamide; Maleimide-PEG5-Val-Cit-PAB-Ornithinamide-Carbamate-Quinoline Indolizine; ADC Linker-Payload Intermediate; Val-Cit-PAB-Orn-Carbamate payload precursor; Targeted Therapy Synthesis Intermediate; Bioconjugation-Reactive Ornithinamide
EINECS	Contact for details

Quality Control

This high-value synthetic intermediate is produced under strict quality control protocols in a cGMP-compliant environment to ensure batch-to-batch consistency and integrity. Each lot is characterized using advanced analytical techniques including HPLC, LC-MS, and NMR to confirm identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider under an inert atmosphere. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.