Description

2′-(Amino-κN)[1,1′-biphenyl]-2-yl-κC][2′-[(1,1-dimethylethyl)phenylphosphino-κP]-N2,N2,N6,N6-tetramethyl[1,1′-biphenyl]-2,6-diamine](methanesulfonato-κO)palladium is a sophisticated, pre-formed palladium catalyst complex designed for high-performance cross-coupling reactions. This compound matters because it offers exceptional activity and selectivity, enabling the efficient synthesis of complex pharmaceutical intermediates and fine chemicals under mild conditions. It is primarily needed by R&D scientists and process chemists in the pharmaceutical, agrochemical, and advanced materials industries who require reliable and highly active catalysts for constructing carbon-carbon and carbon-heteroatom bonds.

Application

• Pharmaceutical Intermediate Synthesis: A key catalyst for Buchwald-Hartwig amination, Suzuki-Miyaura, and other palladium-catalyzed cross-couplings in API development.
• Agrochemical Manufacturing: Used in the synthesis of complex, nitrogen-containing active ingredients and novel herbicide/pesticide compounds.
• Materials Science Research: Facilitates the construction of conjugated organic molecules for OLEDs, organic semiconductors, and functional polymers.
• Process Chemistry & Scale-up: Employed in pilot plant and manufacturing-scale reactions due to its stability and consistent performance.
• Academic & Industrial R&D: A valuable tool for methodological development and exploring new chemical spaces in synthetic organic chemistry.
• Fine Chemical Production: Enables the efficient and selective synthesis of specialty chemicals, flavors, and fragrances.

Basic Information

Item	Details
Product Name	2′-(Amino-κN)[1,1′-biphenyl]-2-yl-κC][2′-[(1,1-dimethylethyl)phenylphosphino-κP]-N2,N2,N6,N6-tetramethyl[1,1′-biphenyl]-2,6-diamine](methanesulfonato-κO)palladium
CAS No.	1661042-31-4
Molecular Formula	C41H48N3O3PPdS
Molecular Weight	820.27 g/mol
Synonyms	Buchwald Palladium Precatalyst G4; Palladium G4; t-BuBrettPhos Pd G4 Methanesulfonate; [2′-(Amino-κN)[1,1′-biphenyl]-2-yl-κC][2′-[(1,1-dimethylethyl)phenylphosphino-κP]-N2,N2,N6,N6-tetramethyl[1,1′-biphenyl]-2,6-diamine](methanesulfonato-κO)palladium; tBuBrettPhos Pd G4; Pd G4; BrettPhos-based Pd Catalyst; (t-BuBrettPhos)Pd(4-ABA)OMs
EINECS	Contact for details

Quality Control

Our 2′-(Amino-κN)[1,1′-biphenyl]-2-yl-κC][2′-[(1,1-dimethylethyl)phenylphosphino-κP]-N2,N2,N6,N6-tetramethyl[1,1′-biphenyl]-2,6-diamine](methanesulfonato-κO)palladium is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and elemental analysis, to ensure high purity and catalytic activity. Certificates of Analysis (COA) detailing all specifications are provided to guarantee traceability and batch-to-batch consistency for your critical R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C. This compound is easily oxidized and light-sensitive; prolonged exposure to air, moisture, or light may reduce catalytic activity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Pd Content (ICP-MS)	11.5 - 13.5 %
Solubility	Soluble in common organic solvents (DCM, THF, Toluene)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.