Description

3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-8-Methoxy-7-[(4aR,7aR)-octahydro-1-Methyl-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-, hydrochloride (1:1), rel- is a high-purity, structurally complex pharmaceutical intermediate. This compound is critical for research and development in the synthesis of novel active pharmaceutical ingredients (APIs), particularly within the fluoroquinolone antibiotic class. It is primarily sought by pharmaceutical manufacturers, contract research organizations (CROs), and advanced chemical synthesis laboratories requiring precise molecular building blocks for drug discovery and process development.

Application

• Pharmaceutical Intermediate: Key synthetic precursor in the development of next-generation fluoroquinolone antibacterial agents.
• Active Pharmaceutical Ingredient (API) Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and medicinal chemistry optimization.
• Process Chemistry & Scale-Up: Used in route scouting and optimization for the commercial-scale manufacturing of target drug molecules.
• Reference Standard: High-purity material for analytical method development, validation, and quality control testing in pharmaceutical production.
• Biochemical Research: Tool compound for investigating bacterial DNA gyrase and topoisomerase IV inhibition mechanisms.

Basic Information

Product Name	3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-8-Methoxy-7-[(4aR,7aR)-octahydro-1-Methyl-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-, hydrochloride (1:1), rel-
CAS No.	1346600-12-1
Molecular Formula	C22H27FN4O4 · HCl
Molecular Weight	466.94 g/mol (Free base: 430.48 g/mol)
Synonyms	rel-(3R,4aR,7aR)-1-Cyclopropyl-6-fluoro-8-methoxy-7-(1-methyloctahydro-6H-pyrrolo[3,4-b]pyridin-6-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride; WCK 771 hydrochloride (intermediate); (R)-Levonadifloxacin intermediate hydrochloride; Levonadifloxacin impurity/intermediate; 1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(octahydro-1-methyl-6H-pyrrolo[3,4-b]pyridin-6-yl)-4-oxo-3-quinolinecarboxylic acid hydrochloride, rel-; Nadifloxacin related compound; Anti-bacterial quinoline derivative intermediate.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and scale-up work. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and MS. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, identity, and impurity profiles. We support compliance with ICH guidelines and can tailor specifications to meet the requirements of cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.2%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.