Description

(2E,4R)-4-[(1R,3aS,4E,7aR)-4-[(2E)-2-[(3S,5R)-3,5-Bis[[(tert-butyl)dimethylsilyl]oxy]-2-methylenecyclohexylidene]ethylidene]octahydro-7a-methyl-1H-inden-1-yl]-1-cyclopropyl-2-penten-1-one is a sophisticated, high-purity synthetic intermediate characterized by its complex stereochemistry and protective silyl ether groups. This compound is of critical importance in advanced organic synthesis, particularly for constructing intricate molecular architectures found in pharmaceuticals and bioactive molecules. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, where it serves as a key chiral building block.

Application

• Pharmaceutical Intermediate: A crucial chiral precursor in the multi-step synthesis of complex drug candidates, particularly in steroid and terpenoid-related research.
• Advanced Organic Synthesis: Used as a specialized building block for constructing complex natural product analogs and molecular scaffolds with defined stereochemistry.
• Medicinal Chemistry Research: Enables the exploration of structure-activity relationships (SAR) by providing a versatile, protected intermediate for further functionalization.
• Process Chemistry Development: Serves as a reference standard or a key material in scaling up synthetic routes from laboratory to pilot plant scale.
• Asymmetric Synthesis: Leverages its multiple chiral centers for the stereoselective synthesis of target molecules in high enantiomeric purity.

Basic Information

Item	Details
Product Name	(2E,4R)-4-[(1R,3aS,4E,7aR)-4-[(2E)-2-[(3S,5R)-3,5-Bis[[(tert-butyl)dimethylsilyl]oxy]-2-methylenecyclohexylidene]ethylidene]octahydro-7a-methyl-1H-inden-1-yl]-1-cyclopropyl-2-penten-1-one
CAS No.	112849-17-9
Molecular Formula	C41H70O3Si2
Molecular Weight	667.2 g/mol
Synonyms	1-Cyclopropyl-2-penten-1-one, (2E,4R)-4-[(1R,3aS,4E,7aR)-4-[(2E)-2-[(3S,5R)-3,5-Bis[[(tert-butyl)dimethylsilyl]oxy]-2-methylenecyclohexylidene]ethylidene]octahydro-7a-methyl-1H-inden-1-yl]-; (2E,4R)-4-[(1R,3aS,4E,7aR)-4-[(2E)-2-[(3S,5R)-3,5-Bis(TBDMS-oxy)-2-methylenecyclohexylidene]ethylidene]octahydro-7a-methyl-1H-inden-1-yl]-1-cyclopropyl-2-penten-1-one; TBS-protected steroid synthesis intermediate; Chiral enone intermediate with TBDMS groups.
EINECS	Contact for details

Quality Control

Our (2E,4R)-4-[(1R,3aS,4E,7aR)-4-[(2E)-2-[(3S,5R)-3,5-Bis[[(tert-butyl)dimethylsilyl]oxy]-2-methylenecyclohexylidene]ethylidene]octahydro-7a-methyl-1H-inden-1-yl]-1-cyclopropyl-2-penten-1-one is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for research and development. All products undergo rigorous analytical testing, including HPLC, NMR, and chiral analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to minimize oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated area, away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.