Description

2-Bromo-1-Fluoro-4-Methanesulfonylbenzene is a high-purity, multi-functional aromatic building block of significant interest in advanced organic synthesis. Its value lies in the strategic combination of bromo, fluoro, and methanesulfonyl substituents, which act as versatile handles for cross-coupling reactions and further functionalization. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients and complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting new therapeutic agents.
• Agrochemical Synthesis: Used in the research and production of advanced crop protection chemicals, herbicides, and fungicides.
• Material Science Research: Serves as a precursor for synthesizing specialized monomers, ligands, or functional materials with tailored electronic properties.
• Cross-Coupling Reactions: The bromine atom is an excellent site for palladium-catalyzed reactions like Suzuki, Negishi, or Buchwald-Hartwig amination.
• Fluorine Chemistry: The fluorine substituent is valuable for modulating lipophilicity, metabolic stability, and bioavailability in drug design.
• Sulfone Chemistry: The methanesulfonyl group can participate in various transformations, including as an activating or directing group in synthesis.

Basic Information

Item	Detail
Product Name	2-Bromo-1-Fluoro-4-Methanesulfonylbenzene
CAS No.	959961-65-0
Molecular Formula	C7H6BrFO2S
Molecular Weight	253.09 g/mol
Synonyms	1-Bromo-2-fluoro-4-(methylsulfonyl)benzene; 4-Bromo-3-fluorophenyl methyl sulfone; 2-Fluoro-4-(methylsulfonyl)bromobenzene; 2-Bromo-1-fluoro-4-(methylsulfonyl)benzene; 3-Fluoro-4-bromophenyl methyl sulfone; Methyl 4-bromo-3-fluorophenyl sulfone; (4-Bromo-3-fluorophenyl)(methyl)sulfone
EINECS	Contact for details

Quality Control

Our 2-Bromo-1-Fluoro-4-Methanesulfonylbenzene is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.