Description

4-Chloro-6-Methoxy-2-(Trifluoromethyl)Quinoline-3-Carbonitrile is a high-value, multi-functional heterocyclic building block designed for advanced chemical synthesis. This compound is engineered to serve as a critical intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique trifluoromethyl and cyano substituents offer significant advantages in modulating biological activity and physicochemical properties. It is primarily sought after by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in oncology, antiviral, and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging the trifluoromethyl group for enhanced efficacy and environmental profile.
• Material Science Research: Serves as a building block for creating advanced organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors.
• Ligand and Catalyst Development: Employed in the design of novel ligands for catalysis and metal-organic frameworks (MOFs) due to its rigid quinoline backbone and functional handles.
• Fluorescent Probe Synthesis: Utilized as a core structure for developing sensitive fluorescent dyes and biological imaging agents.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects requiring specialized fluorinated heterocycles.

Basic Information

Product Name	4-Chloro-6-Methoxy-2-(Trifluoromethyl)Quinoline-3-Carbonitrile
CAS No.	959271-96-6
Molecular Formula	C₁₂H₆ClF₃N₂O
Molecular Weight	286.64 g/mol
Synonyms	4-Chloro-6-methoxy-2-(trifluoromethyl)-3-quinolinecarbonitrile; 3-Quinolinecarbonitrile, 4-chloro-6-methoxy-2-(trifluoromethyl)-; 4-Chloro-6-methoxy-2-trifluoromethylquinoline-3-carbonitrile; 2-(Trifluoromethyl)-4-chloro-6-methoxyquinoline-3-carbonitrile; 959271-96-6; Quinoline-3-carbonitrile, 4-chloro-6-methoxy-2-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Every batch of 4-Chloro-6-Methoxy-2-(Trifluoromethyl)Quinoline-3-Carbonitrile is produced and tested under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the high standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.