Description

4-Chloro-8-Fluoro-2-(Trifluoromethyl)Quinazoline is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. Its unique halogenated and trifluoromethylated quinazoline core makes it a critical intermediate for developing novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is primarily sought by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for creating compounds with enhanced biological activity and physicochemical properties.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of targeted small-molecule drugs, particularly kinase inhibitors and other biologically active quinazoline derivatives.
• Agrochemical Research: Used to develop new generations of herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Material Science: Serves as a building block for creating advanced organic electronic materials, such as OLED (Organic Light-Emitting Diode) components.
• Chemical Synthesis: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to introduce complex quinazoline scaffolds into larger molecular architectures.
• Fluorine Chemistry: The presence of fluorine and trifluoromethyl groups makes it valuable for studying structure-activity relationships (SAR) and metabolic stability in drug discovery.

Basic Information

Product Name	4-Chloro-8-Fluoro-2-(Trifluoromethyl)Quinazoline
CAS No.	959238-18-7
Molecular Formula	C9H3ClF4N2
Molecular Weight	250.58 g/mol
Synonyms	4-Chloro-8-fluoro-2-(trifluoromethyl)quinazoline; Quinazoline, 4-chloro-8-fluoro-2-(trifluoromethyl)-; 8-Fluoro-4-chloro-2-trifluoromethylquinazoline; 2-(Trifluoromethyl)-4-chloro-8-fluoroquinazoline; 4-Chloro-8-fluoro-2-trifluoromethylquinazoline; CAS 959238-18-7
EINECS	Contact for details

Quality Control

Our 4-Chloro-8-Fluoro-2-(Trifluoromethyl)Quinazoline is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment ensures the material meets the high standards required for research and cGMP-grade synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.