Description

2,4-Dichloro-8-(Trifluoromethyl)Quinazoline is a high-value, multi-functional heterocyclic building block of significant importance in advanced organic synthesis. Its core value lies in its versatile reactivity, where the dichloro and trifluoromethyl substituents on the quinazoline scaffold enable precise derivatization for creating complex molecular architectures. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, as well as by material scientists exploring advanced functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly kinase inhibitors and other biologically active heterocycles.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the bioactivity of the quinazoline core.
• Material Science: Serves as a building block for creating organic electronic materials, such as OLED (Organic Light-Emitting Diode) components or conductive polymers.
• Chemical Synthesis: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to introduce complex functionalities.
• Ligand and Catalyst Development: Useful for constructing novel chelating ligands or organocatalysts for asymmetric synthesis.
• Fluorine Chemistry Studies: The trifluoromethyl group makes it a valuable substrate for research into fluorinated compounds and their unique properties.

Basic Information

Product Name	2,4-Dichloro-8-(Trifluoromethyl)Quinazoline
CAS No.	959237-52-6
Molecular Formula	C9H3Cl2F3N2
Molecular Weight	267.04 g/mol
Synonyms	8-(Trifluoromethyl)-2,4-dichloroquinazoline; 2,4-Dichloro-8-(trifluoromethyl)quinazoline; Quinazoline, 2,4-dichloro-8-(trifluoromethyl)-; 2,4-Dichloro-8-trifluoromethylquinazoline
EINECS	Contact for details

Quality Control

Our 2,4-Dichloro-8-(Trifluoromethyl)Quinazoline is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, meeting the stringent requirements of research and process development. We provide comprehensive analytical data including HPLC, NMR, and mass spectrometry. Certificates of Analysis (COA) are available for every batch upon request, detailing purity and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.