Description

2,4-Dichloro-8-(Trifluoromethoxy)Quinazoline is a high-value, multi-functional heterocyclic building block. Its unique structure, featuring both chloro and trifluoromethoxy substituents, makes it a critical intermediate for synthesizing advanced pharmaceutical compounds and agrochemicals. This compound is primarily sought after by R&D chemists and process development scientists in the life sciences sector for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of kinase inhibitors, anticancer agents, and other small-molecule therapeutics.
• Agrochemical Research: Used in developing new herbicides, fungicides, and insecticides, leveraging the bioactivity of the quinazoline core.
• Material Science: Serves as a precursor for functionalized organic materials and liquid crystals.
• Chemical Synthesis: Versatile scaffold for further functionalization via nucleophilic aromatic substitution (SNAr) reactions at the chloro positions.
• Academic & Contract Research: Essential for medicinal chemistry programs and structure-activity relationship (SAR) studies in university and CRO laboratories.

Basic Information

Product Name	2,4-Dichloro-8-(trifluoromethoxy)quinazoline
CAS No.	959237-48-0
Molecular Formula	C9H3Cl2F3N2O
Molecular Weight	283.04 g/mol
Synonyms	2,4-Dichloro-8-(trifluoromethoxy)quinazoline; 8-(Trifluoromethoxy)-2,4-dichloroquinazoline; Quinazoline, 2,4-dichloro-8-(trifluoromethoxy)-; 959237-48-0; 2,4-Dichloro-8-trifluoromethoxyquinazoline
EINECS	Contact for details

Quality Control

Our 2,4-Dichloro-8-(trifluoromethoxy)quinazoline is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and NMR/LC-MS for identity confirmation, to ensure it meets the stringent requirements of pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with each shipment to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.