Description

8-(Trifluoromethoxy)Quinazoline-2,4(1H,3H)-Dione is a high-purity, advanced pharmaceutical intermediate and heterocyclic building block. This compound is valued for its unique trifluoromethoxy-substituted quinazoline dione core, which is critical for imparting desirable metabolic stability and lipophilicity in active molecules. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for the development of novel therapeutic agents and high-performance materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and synthesis of novel drug candidates, particularly in oncology, CNS, and anti-infective therapeutic areas.
• Agrochemical Research: Serves as a building block for developing new herbicides, fungicides, and insecticides with enhanced efficacy.
• Chemical Biology & Proteomics: Used as a specialized scaffold or probe in biochemical research and target identification studies.
• Material Science: A precursor for synthesizing advanced organic electronic materials and liquid crystals.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of client-specific target molecules under cGMP or research-grade conditions.

Basic Information

Product Name	8-(Trifluoromethoxy)Quinazoline-2,4(1H,3H)-Dione
CAS No.	959236-83-0
Molecular Formula	C10H5F3N2O3
Molecular Weight	258.16 g/mol
Synonyms	8-(Trifluoromethoxy)-1H,3H-quinazoline-2,4-dione; 8-(Trifluoromethoxy)quinazoline-2,4-diol; 2,4-Dihydroxy-8-(trifluoromethoxy)quinazoline; 8-(Trifluoromethoxy)-2,4(1H,3H)-quinazolinedione; 959236-83-0; TFMO-Quinazoline Dione
EINECS	Contact for details

Quality Control

Our 8-(Trifluoromethoxy)Quinazoline-2,4(1H,3H)-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to ISO 9001 standards, and we can support development projects requiring research-grade to cGMP-compliant material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.