Description

Methyl 4-Chloro-2-(Trifluoromethyl)Quinoline-6-Carboxylate is a high-value, multi-functional heterocyclic building block designed for advanced chemical synthesis. This compound matters for its role as a critical intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where its unique quinoline scaffold and halogen/trifluoromethyl substituents enable precise molecular modifications. It is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce complex, functionalized heterocycles into their target molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in oncology, antiviral, and anti-inflammatory research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the quinoline core.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as OLEDs or conductive polymers, due to its electron-deficient aromatic system.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for metal-catalyzed cross-coupling reactions and other catalytic processes.
• Chemical Biology Probes: Utilized to create fluorescent tags or molecular probes for studying biological systems and enzyme functions.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	Methyl 4-Chloro-2-(Trifluoromethyl)Quinoline-6-Carboxylate
CAS No.	958332-63-3
Molecular Formula	C₁₂H₇ClF₃NO₂
Molecular Weight	289.64 g/mol
Synonyms	6-Quinolinecarboxylic acid, 4-chloro-2-(trifluoromethyl)-, methyl ester; Methyl 4-chloro-2-(trifluoromethyl)quinoline-6-carboxylate; 4-Chloro-2-trifluoromethylquinoline-6-carboxylic acid methyl ester; 958332-63-3; 4-Chloro-2-(trifluoromethyl)-6-quinolinecarboxylic acid methyl ester; Methyl 4-chloro-2-trifluoromethylquinoline-6-carboxylate
EINECS	Contact for details

Quality Control

Our production of Methyl 4-Chloro-2-(Trifluoromethyl)Quinoline-6-Carboxylate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to verify identity, potency, and impurity profiles. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support cGMP (current Good Manufacturing Practice) standards for pharmaceutical-grade material upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.