Description

Boc-(Trans)-4-(2-Methyl-Phenyl)-Pyrrolidine-3-Carboxylic Acid is a high-purity, protected amino acid derivative essential for advanced organic synthesis. This compound serves as a critical chiral building block for constructing complex molecular architectures, offering precise stereochemical control. It is primarily utilized by pharmaceutical R&D and fine chemical manufacturers for the development of novel active pharmaceutical ingredients (APIs) and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic agents, particularly in medicinal chemistry programs.
• Peptidomimetic Synthesis: Used to incorporate constrained, non-natural amino acid motifs into peptide analogs to enhance stability and biological activity.
• Chemical Biology Probes: Employed in the synthesis of specialized molecular tools for studying enzyme function and protein-protein interactions.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for the synthesis of chiral ligands used in enantioselective catalytic reactions.
• Custom Synthesis Building Block: Provides a versatile scaffold for contract research organizations (CROs) and fine chemical companies engaged in custom synthesis projects.

Basic Information

Product Name	Boc-(Trans)-4-(2-Methyl-Phenyl)-Pyrrolidine-3-Carboxylic Acid
CAS No.	957476-23-2
Molecular Formula	C18H25NO4
Molecular Weight	319.40 g/mol
Synonyms	(3R,4R)-1-tert-Butoxycarbonyl-4-(2-methylphenyl)pyrrolidine-3-carboxylic acid; (3R,4R)-1-Boc-4-(o-tolyl)pyrrolidine-3-carboxylic acid; 1-Boc-4-(2-methylphenyl)-3-pyrrolidinecarboxylic acid; trans-1-Boc-4-(2-methylphenyl)pyrrolidine-3-carboxylic acid; (3R,4R)-1-(tert-Butoxycarbonyl)-4-(2-methylphenyl)pyrrolidine-3-carboxylic acid; 1-N-Boc-4-(2-methylphenyl)-3-pyrrolidinecarboxylic acid; Boc-(2-methylphenyl)proline derivative
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized using advanced analytical techniques to confirm identity, purity, and chiral integrity. Certificates of Analysis (COA) detailing specific results for purity (HPLC), chiral purity, and related substances are provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.