Description

(3Ar,4S,9Bs)-8-Chloro-6-Methyl-3A,4,5,9B-Tetrahydro-3H-Cyclopenta[C]Quinoline-4-Carboxylic Acid is a high-purity, synthetically derived chiral intermediate of significant importance in advanced pharmaceutical research and development. Its complex polycyclic structure makes it a valuable building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders. This compound is essential for medicinal chemists and process development scientists in pharmaceutical, biotechnology, and fine chemical industries seeking to develop new therapeutic agents with high stereochemical purity.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research-scale synthesis of potential drug candidates, especially for neurological and psychiatric applications.
• Medicinal Chemistry Research: Used as a sophisticated scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry Development: Serves as a critical intermediate for developing and scaling up enantioselective synthetic routes for new chemical entities (NCEs).
• Reference Standard: Employed as an analytical standard for method development and quality control in API manufacturing.
• Academic & Institutional Research: Utilized in universities and research institutes for studying novel organic reactions and synthesizing complex heterocyclic compounds.
• Precursor for Analogue Synthesis: The carboxylic acid functional group allows for further derivatization (e.g., amide formation, esterification) to create libraries of novel analogues for biological screening.

Basic Information

Product Name	(3Ar,4S,9Bs)-8-Chloro-6-Methyl-3A,4,5,9B-Tetrahydro-3H-Cyclopenta[C]Quinoline-4-Carboxylic Acid
CAS No.	956629-74-6
Molecular Formula	C15H14ClNO2
Molecular Weight	275.73 g/mol
Synonyms	8-Chloro-6-methyl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4-carboxylic acid; (3aR,4S,9bS)-8-Chloro-6-methyl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4-carboxylic acid; 4-Cyclopenta[c]quinolinecarboxylic acid, 3a,4,5,9b-tetrahydro-8-chloro-6-methyl-, (3aR,4S,9bS)-; UNII-9V6J2J8R3K; 9V6J2J8R3K; SCHEMBL21826227; AOB31117; ZINC000253899793.
EINECS	Contact for details

Quality Control

Our (3Ar,4S,9Bs)-8-Chloro-6-Methyl-3A,4,5,9B-Tetrahydro-3H-Cyclopenta[C]Quinoline-4-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination by HPLC, to ensure it meets the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.