Description

4-Amino-8-Fluoroquinoline-3-Carboxylic Acid Ethyl Ester is a high-purity, advanced pharmaceutical intermediate belonging to the fluoroquinolone class of compounds. This compound is a critical building block in the synthesis of novel antibacterial agents, offering a strategic point for molecular diversification and optimization. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of next-generation antibiotics and other therapeutic molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel fluoroquinolone-based antibacterial drugs.
• Antibiotic Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies to develop new antimicrobial agents with improved efficacy and reduced resistance.
• Chemical Synthesis Building Block: Serves as a versatile scaffold for introducing the 4-amino-8-fluoroquinoline core into more complex molecular architectures.
• Active Pharmaceutical Ingredient (API) Manufacturing: Employed in the production scale-up of experimental and approved antibiotic compounds.
• Biochemical Research: Utilized as a tool compound in microbiological and enzymatic assays to study bacterial inhibition mechanisms.

Basic Information

Product Name	4-Amino-8-Fluoroquinoline-3-Carboxylic Acid Ethyl Ester
CAS No.	955328-46-8
Molecular Formula	C₁₂H₁₁FN₂O₂
Molecular Weight	234.23 g/mol
Synonyms	Ethyl 4-Amino-8-fluoroquinoline-3-carboxylate; 8-Fluoro-4-aminoquinoline-3-carboxylic Acid Ethyl Ester; 4-Amino-8-fluoro-3-quinolinecarboxylic Acid Ethyl Ester; 955328-46-8; 4-Amino-8-fluoroquinoline-3-carboxylic acid ethyl ester; Ethyl 4-amino-8-fluoro-3-quinolinecarboxylate; 3-Quinolinecarboxylic acid, 4-amino-8-fluoro-, ethyl ester
EINECS	Contact for details

Quality Control

Our 4-Amino-8-Fluoroquinoline-3-Carboxylic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and manufacturing. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and away from direct light to maintain stability and purity.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.