Description

4-Chloro-8-Trifluoromethyl-1H-Quinolin-2-One is a high-purity, advanced pharmaceutical intermediate characterized by its unique halogenated quinolinone structure. This compound is of significant commercial importance for its role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. It is primarily sought after by research institutions, custom synthesis organizations, and pharmaceutical companies engaged in the development of new chemical entities.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of novel drug candidates, particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the development of new herbicides and pesticides, leveraging the biological activity of the quinolinone core.
• Material Science Precursor: Serves as a specialized monomer or precursor for the synthesis of functional polymers and advanced organic materials.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and GMP production.

Basic Information

Product Name	4-Chloro-8-Trifluoromethyl-1H-Quinolin-2-One
CAS No.	955288-52-5
Molecular Formula	C10H5ClF3NO
Molecular Weight	247.60 g/mol
Synonyms	4-Chloro-8-(trifluoromethyl)quinolin-2(1H)-one; 8-Trifluoromethyl-4-chloro-1H-quinolin-2-one; 4-Chloro-8-trifluoromethyl-2-quinolinone; 2(1H)-Quinolinone, 4-chloro-8-(trifluoromethyl)-; 955288-52-5; 4-Chloro-8-trifluoromethylquinolin-2(1H)-one
EINECS	Contact for details

Quality Control

Our 4-Chloro-8-Trifluoromethyl-1H-Quinolin-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.