Description

6-(Difluoromethoxy)-1,2,3,4-Tetrahydroquinoline is a high-purity, advanced pharmaceutical intermediate characterized by its unique difluoromethoxy-substituted tetrahydroquinoline scaffold. This compound is of significant commercial importance as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring specific fluorine substitution for enhanced metabolic stability and bioavailability. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical industries for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and development of new-generation pesticides and herbicides, where the difluoromethoxy group can improve biological activity and environmental profile.
• Chemical Research & Development: Serves as a versatile scaffold for medicinal chemists to explore structure-activity relationships (SAR) in novel compound libraries.
• Fluorinated Compound Manufacturing: Employed in the production of various specialty fluorinated organic chemicals for advanced material and life science applications.

Basic Information

Product Name	6-(Difluoromethoxy)-1,2,3,4-Tetrahydroquinoline
CAS No.	954264-62-1
Molecular Formula	C10H11F2NO
Molecular Weight	199.20 g/mol
Synonyms	6-(Difluoromethoxy)-1,2,3,4-tetrahydroquinoline; 1,2,3,4-Tetrahydro-6-(difluoromethoxy)quinoline; Quinoline, 1,2,3,4-tetrahydro-6-(difluoromethoxy)-; 6-Difluoromethoxy-1,2,3,4-tetrahydroquinoline; 954264-62-1; 6-(Difluoromethoxy)tetrahydroquinoline
EINECS	Contact for details

Quality Control

Our 6-(Difluoromethoxy)-1,2,3,4-Tetrahydroquinoline is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials. Due to its light-sensitive nature, containers should be kept in the original packaging or amber glass until use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.