Description

3-(Quinolin-8-Yloxy)-Azetidine-1-Carboxylic Acid tert-Butyl Ester is a high-value, protected azetidine derivative that serves as a critical synthetic intermediate in modern organic chemistry. Its core value lies in providing a versatile, functionalized scaffold for constructing complex nitrogen-containing heterocycles, which are pivotal in pharmaceutical discovery and advanced material science. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity building blocks for lead optimization and novel compound library synthesis.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Research: Used in the development of new active ingredients for crop protection products, leveraging its heterocyclic structure for bioactivity.
• Chemical Biology Probes: Serves as a precursor for creating labeled compounds or molecular probes to study biological pathways and enzyme functions.
• Ligand & Catalyst Development: Utilized in the design and synthesis of novel ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Academic & Contract Research: A valuable reagent for methodology development and exploring new chemical space in university and CRO (Contract Research Organization) laboratories.
• Peptidomimetics & Conformationally Restricted Analogs: The azetidine ring is employed to introduce rigidity into peptide chains, creating more stable and potent analogs for therapeutic applications.

Basic Information

Product Name	3-(Quinolin-8-Yloxy)-Azetidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	954236-10-3
Molecular Formula	C17H20N2O3
Molecular Weight	300.36 g/mol
Synonyms	1-Boc-3-(8-quinolyloxy)azetidine; tert-Butyl 3-(quinolin-8-yloxy)azetidine-1-carboxylate; 3-(8-Quinolyloxy)-1-(tert-butoxycarbonyl)azetidine; 1-(tert-Butoxycarbonyl)-3-(8-quinolyloxy)azetidine; 3-(Quinolin-8-yloxy)azetidine-1-carboxylic acid tert-butyl ester; Azetidine-1-carboxylic acid, 3-(8-quinolyloxy)-, 1,1-dimethylethyl ester; 954236-10-3; Boc-3-(8-quinolyloxy)azetidine.
EINECS	Contact for details

Quality Control

Our 3-(Quinolin-8-Yloxy)-Azetidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with the standards expected for pharmaceutical intermediates, supporting our clients' regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep away from strong acids and incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.